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    • CommentAuthorbilleld
    • CommentTimeNov 24th 2010
     
    http://www.dailymail.co.uk/health/article-1332185/Alzheimers-prevented-cocktail-cheap-drugs-including-metformin-resveratrol.html?printingPage=true

    My son just sent this to me. Seems to have been published yesterday. Anybody know about this?

    bill
    • CommentAuthorAdmin
    • CommentTimeNov 24th 2010
     
    Bill,

    Yes, the direct link to the article is up on my home page under Breaking News. They still need to have trials, but it should be on the fast track because it is already an approved drug. The article failed to mention that Metformin causes kidney damage, and that is why many diabetics (including my husband) are taken off it after a few years. It certainly didn't prevent him from getting AD.

    joang
  1.  
    My wife has been on metformin for her diabetes. I agree with Joang, it sure didn't prevent her getting AD.
    •  
      CommentAuthorJeanetteB
    • CommentTimeNov 26th 2010
     
    Dh was also on metformin and it did not prevent AD. He has now been taken off it because the pills were so big and he was refusing to swallow them.
    • CommentAuthormary22033
    • CommentTimeNov 27th 2010
     
    I was excited when I read an earlier article about Metformin in German studies. (http://www.allheadlinenews.com/articles/7020635217?Diabetes%20Drug%20May%20Treat%20Alzheimer's%20Disease) and even more excited when I found a clinical trial for the drug in Mild Cognitive Impairment (http://clinicaltrials.gov/ct2/show/NCT00620191?term=Metformin+Alzheimer%27s&rank=1).

    But the eligibility for the trial required my husband to score an 8 or less on a delayed paragraph recall - and of course he scored a 9. He absolutely bombed the list recall, but that wasn't coinsidered in the eligibility.

    After reading the comments of Joan, Marsh, and Jeanette, I don't feel so badly now.

    The one element that interested me at the time was that the Metformin cleared the tau in the brain, as opposed to most other drugs which target beta amyloid. The latter seems to me a dead end based on trial results. I think we will see more tau drugs, if we could only qualify perfectly for the trials!

    Here are a few more links on the subject I had bookmarked:

    http://news.oneindia.in/2010/10/19/novelstudy-offers-hope-for-new-class-of-alzheimersdrugs.html

    http://www.medicalnewstoday.com/articles/151234.php

    http://7thspace.com/headlines/362179/phenothiazine_mediated_rescue_of_cognition_in_tau_transgenic_mice_requires_neuroprotection_and_reduced_soluble_tau_burden_.html