I have brought to the top the discussions on drug trials/vaccines for you. Many of our members' spouses are/were in the BAP trial. Some have finished the trial, and are now getting the vaccine, but I think they mentioned it within other discussions, so I can't find those.
I'm not sure if the IGIV is the same one or different.
I looked into it when they started it here in Portland. There was an article last week about the phase 2 trials that showed some promise. I think of all, since this infusion has been going used for years with other diseases, it seems safer. Again, the problem is my hb does not like the testing that they do. I think if I pushed it he would.
IGIV (Immune Globulin Intravenous) made from pooled human plasma containing antibodies that bind to amyloid-the substance that abnormally accumulates as plaques in the brains of patients with AZ.
As with any trial, I'm concerned with the side effects. We seem to be at a calm place right now and the decision to take a chance on doing anything that might bring back undesirable behavior is is weighing on my decision.
I was hoping to find someone who had tried it and could give feedback. I know there is no blanket answer. Just looking to sound off with someone who had tried it.
All I can say is to google it, just the Alzheimer Asscoc. site, and maybe find forums for diseases where it has been approved for years to find others who have done it. Of all them, this one does seem to have least risk. If you find out more or decide to go for it, let us know.
Thanks for trying to help. I think we've decided to try it. I'll let you know how it goes. It's an eighteen month trial so it will be a while before we see results. If we end up with a placebo then we'll never know.
I have looked over what literature I could find. IVIg (Intravenous Immunoglobulin) has been safely used for many years for various immune diseases. A recent study suggested that it might be useful in preventing Alzheimer's. This study was done by comparing individuals who received IVIg for whatever reason against a large group who had not and looking at the development of Alzheimer's. They suggested a 40%+ reduction in the onset of AD. This is very preliminary work and needs to be repeated with a much larger group of patients. Another study has been started to see if IVIg has any benefit in early AD. This is still in the very early phase. Previous use of IVIg for other conditions has been generally very safe, but obviously nothing is known about what will happen to the AD patient if the plaques are somewhat dissolved. Since my wife is now at stage 6 I would not expect anything useful from the use of IVIg in her. If she were in an early stage I might consider a trial, but I would probably want to see what happened to other patients who go it before starting her on it.